Drug Design Course, Hugo Kubinyi

for a download of lectures in PDF format, click here.

The Search for a Needle in a Haystack

  Haystacks in Provence

Vincent van Gogh, 1888


DRUG DESIGN - A Medicinal Chemistry Course

(first presentation in Sao Paulo, Brazil, November 2002; for technical
 reasons, this course followed a slightly different schedule).

Hugo Kubinyi
Weisenheim am Sand, Germany. E-mail kubinyi@t-online.de

Monday morning: Lead Search and Optimisation 
	09:00-10:00	Drug Discovery							
	10:00-11:00	Serendipity and Rational Design					
	Break
	11:30-12:30	Chemogenomics
Monday afternoon: Ligand-Receptor Interactions 
	14:30-15:30	Ligand-Receptor Interactions					
	15:30-16:30	Hydrogen Bonds and Biological Activities
Tuesday morning: Special Topics in Medicinal Chemistry 
	09:00-10:00	Chemical Similarity and Biological Activities		
	10:00-11:00	Drug Metabolism						
	Break
	11:30-12:30	Peptidomimetics and Prodrugs
Tuesday afternoon: Combinatorial Chemistry 
	14:30-15:30	Combinatorial Chemistry Technology			
	15:30-16:30	Combinatorial Chemistry in Drug Research
Wednesday morning: Quantitative Structure-Activity Relationships (QSAR) 
	09:00-10:00	QSAR Parameters						
	10:00-11:00	QSAR - Hansch and Free Wilson Analyses		
	Break
	11:30-12:30	Variable Selection and Model Validation
Wednesday afternoon: QSAR and 3D QSAR Models and Applications 
	14:30-15:30	Nonlinear QSAR and 3D QSAR				
	15:30-16:00	QSAR Examples
	Break
	16:30-...	   QSAR Examples - Calculations with the Program BILIN (optional)
Thursday morning: Ligand Design 
	09:00-10:00	Structure-Based Ligand Design				
	10:00-11:00	Computer-Aided Ligand Design				
	Break
	11:30-12:30	Pharmacophore Analyses
Thursday afternoon: Virtual Screening and Combinatorial Design 
	14:30-15:30	Virtual Screening
	15:30-16:30	Combinatorial Ligand Design
Friday morning: Drug Design Applications and Problems 
	09:00-10:00	Serine Proteases and their Inhibitors 
	10:00-11:00	Thrombin Inhibitor Design
	Break
	11:30-12:30	Problems in Drug Design
Friday afternoon 
	14:30-...		General Discussion (optional)

Download of all  COURSE LECTURES


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